Highly Bioactive Elastomeric Hybrid Nanoceramics for Guiding Bone Tissue Regeneration

Conventional bioactive ceramic implants possess high osteogenic ability but exhibit poor machinability and brittleness, which limit their wide applications. In this study, we report an elastomeric machinable nanoceramic-based hybrid membrane that is formed by nanohydroxyapatite-reinforced matrix (poly(dimethylsilicone)-bioactive glass-poly(caprolactone) (nHA-PBP)) using a modified sol-gel process. The composed of polydimethylsiloxane glass nanogel. effect the nHA contents (0, 20, 30, 40 50 wt%) on physicochemical structure biomineralization activity PBP membranes investigated systematically. results show nHA-PBP containing more than 20 wt% highest apatite-forming bioactivity due to optimized hydroxyapatite crystalline phase. NHA-PBP with also good mechanical behavior foldable properties. Furthermore, study in vitro cellular biocompatibility suggests monoliths can enhance osteoblast (MC3T3-E1) attachment proliferation. biomimetic composition, crack-free monolith structure, biological apatite formation make prospective candidate application bone tissue regeneration.